WYE 354-d3
- CAS NO.：1794791-66-4
- Empirical Formula: C24H29N7O5
- Molecular Weight: 495.54
- Update Date: 2022-09-15 14:44:07
What is WYE 354-d3?
The Uses of WYE 354-d3
A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays usin
The Uses of WYE 354-d3
A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.
Safety information for WYE 354-d3
New Products
Elobixibat Acid Bromo Analogue impurity Nintedanib Impurity C/Nintedanib esylate Impurity C Elobixibat Phenol Impurity 7,8-Lactocyanocobalamin/ Cyanocobalamin - Impurity A Hydroxy chloroquine Impurity-C Pantoprazole EP Impurity-D/ Pantoprazole Related Compounds D/N-Methyl Pantoprazole 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. CSA (DL-10-Camphorsulfonic Acid) (1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)boronic acid (14bRS)-2-methyl-1,3,4,14b-tetrahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepin-10(2H)-one (2S)-1-((2S,3S)-3-(2-methylbutyl)-4-oxooxetan-2-yl)pentadecan-2-yl formylleucinate S-(1-(3,5-dichlorophenyl)-2,2,2-trifluoroethyl) ethanethioate 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethane-1-sulfonyl chloride 7-(hydroxymethyl)-3,4-dihydroquinazolin-2(1H)-one 2-(4-Bromophenyl)-1,2-Dihydro-1-Methyl-3h-Pyrazol-3-One Not Publicly Available 1-[[4-(1-Methylethyl)Phenyl]Methyl]-2-Piperazinone (Boc) Not Publicly Available 1-Bromo-4-(1-Bromoethyl) Benzene (Lr)Related products of tetrahydrofuran
![N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea](https://img.chemicalbook.in/CAS2/GIF/1144068-46-1.gif)
You may like
-
Ivermectin Ep Impurity-D 102190-55-6 NLT 95%View Details
102190-55-6 -
Dextromethorphan N-Oxide NLT 95%View Details
210690-24-7 -
2115779-15-0 Pantoprazole EP Impurity E/Pantoprazole Dimer ; Pantoprazole USP Related Compound E NLT 95%View Details
2115779-15-0 -
Paroxetine Related Compound G NLT 95%View Details
1217655-87-2 -
Glycopyrrolate Impurity-I 1404453-68-4 NLT 95%View Details
1404453-68-4 -
Pregablin 5-ene Impurity 1136478-30-2 NLT 95%View Details
1136478-30-2 -
934365-23-8 Terbinafine Impurity-E NLT 95%View Details
934365-23-8 -
Atrovastin pyrilodine lactone 906552-19-0 NLT 95%View Details
906552-19-0