WAY100635

CAS NO.：1092679-51-0
Empirical Formula: C29H38N4O6
Molecular Weight: 538.65
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is WAY100635?

Description

WAY-100635 is a potent, silent antagonist of serotonin 5-HT_1A receptors with an IC₅₀ value of 2.2 nM (K_i = 0.8 nM) for inhibiting 5-HT_1A receptors in rat hippocampal membranes. Because it displays 100-fold selectivity for 5-HT_1A over other 5-HT subtypes, WAY-100635 is classically used to examine the distribution and function of 5-HT_1A receptors. However, WAY-100635 has also been shown to exhibit agonist activity at dopamine D₄ receptors (K_d = 2.4 nM).

Storage

Desiccate at RT

Properties of WAY100635

storage temp.	Store at -20°C
solubility	≥53.9 mg/mL in DMSO; ≥51.2 mg/mL in EtOH; ≥6.08 mg/mL in H2O with ultrasonic
form	solid
color	White to off-white
Water Solubility	Soluble to 25 mM in water

Safety information for WAY100635

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.