Ketanserin
- CAS NO.：74050-98-9
- Empirical Formula: C22H22FN3O3
- Molecular Weight: 395.43
- MDL number: MFCD00083392
- EINECS: 277-680-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-10 21:10:33
What is Ketanserin?
Description
Ketanserin is an antihypertensive agent with antagonist properties at both the serotonin-S2 and α1-adrenergic receptors. Its mechanism of action, while still controversial, may involve interactions at both of these loci.
Chemical properties
Off-White Solid
Originator
Janssen (Belgium)
The Uses of Ketanserin
An antihypertensive, with affinity for multiple GPCR receptors.
The Uses of Ketanserin
receptor antagonist
What are the applications of Application
Ketanserin is a selective serotonin antagonist
Definition
ChEBI: A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
brand name
SEREFREX
Purification Methods
It has been purified by recrystallisation from 4-methyl-3-pentanone [Peeters et al. Cryst Structure Commun 11 375 1982, Kacprowicz et al. J Chromatogr 272 417 1983, Davies et al. J Chromatogr 275 232 1983]. It is an antihypertensive.
Properties of Ketanserin
| Melting point: | 227-235°C |
| Density | 1.280±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMF: 10 mg/mL, clear, colorless |
| pka | 7.5(at 25℃) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,5296 |
| CAS DataBase Reference | 74050-98-9(CAS DataBase Reference) |
Safety information for Ketanserin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. |
Computed Descriptors for Ketanserin
New Products
Cyclopentane-1,2-dione 2,6-Dibromoaniline (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 1-AMino-cyclobutaneMethanol HCl TETRABUTYLAMMONIUM CYANIDE 3-Amino-3-(3-fluorophenyl)propanoic acid 3-Amino-3-(4-methylphenyl)propionic acid 3-AMINO-3-(3-CHLORO-PHENYL)-PROPIONIC ACID Cefuroxime EP Impurity-A N-Nitroso hydroxy Cetrizine EP Impurity-A Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity Lantanoprost rc B Clidinium Bromide Impurity 4 - fluoro- 2 - methoxy- 5 - nitroaniline 1-(2-amino-5-hydroxy phenyl)propan-1-one tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-amino-5-nitrobenzonitrile (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 2-Chloro Benzylcyanide 3,4 Diethoxy Benzylcyanide 3,4 Dimethoxy Benzylcyanide 3-chlorobenzyl cyanideRelated products of tetrahydrofuran
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