VUF 5574
- CAS NO.：280570-45-8
- Empirical Formula: C21H17N5O2
- Molecular Weight: 371.39
- MDL number: MFCD06691423
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:51
What is VUF 5574?
Description
VUF 5574 is an antagonist of the adenosine A3 receptor (Ki = 4.03 nM for the recombinant human receptor). It is greater than 2,500-fold selective for adenosine A3 over A1 and A2A receptors. VUF 5574 (100 nM) decreases phosphorylation of ERK1/2 induced by adenosine in isolated porcine coronary artery smooth muscle cells. It increases oxygen-glucose deprivation-induced reductions in the amplitude of field excitatory postsynaptic potentials (EPSPs) in a rat hippocampal slice model of ischemia when used at a concentration of 100 nM. VUF 5574 (2 μg, intracisternal) reduces sodium nitroprusside-induced heart rate increases in rats.
The Uses of VUF 5574
VUF 5574 is an adenosine A3 receptor antagonist.
What are the applications of Application
VUF 5574 is a selective, competitive and potent human Adenosine A3-R antagonist
Biological Activity
Potent, selective, competitive antagonist for the human adenosine A 3 receptor (K i = 4 nM). Displays ≥ 2500-fold selectivity over A 1 and A 2A receptors.
Properties of VUF 5574
| Melting point: | 257-258 °C |
| Boiling point: | 444.8±45.0 °C(Predicted) |
| Density | 1.360±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO: 1.5 mg/mL, soluble |
| form | solid |
| pka | -2.06±0.43(Predicted) |
| color | white |
Safety information for VUF 5574
Computed Descriptors for VUF 5574
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