VU6007477

CAS NO.：2220141-46-6
Empirical Formula: C24H26N6O2
Molecular Weight: 430.5
Update Date: 2026-04-21 10:31:43

What is VU6007477?

Description

VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat braiplasma Kp = 0.28, Kp,uu = 0.32; mouse Kp = 0.16, Kp,uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures).

Properties of VU6007477

Boiling point:	711.3±60.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
pka	12.07±0.20(Predicted)

Safety information for VU6007477

Computed Descriptors for VU6007477

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