VU6007477
- CAS NO.：2220141-46-6
- Empirical Formula: C24H26N6O2
- Molecular Weight: 430.5
- Update Date: 2025-08-21 16:37:02
What is VU6007477?
Description
VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat braiplasma Kp = 0.28, Kp,uu = 0.32; mouse Kp = 0.16, Kp,uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures).
Properties of VU6007477
| Boiling point: | 711.3±60.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| pka | 12.07±0.20(Predicted) |
Safety information for VU6007477
Computed Descriptors for VU6007477
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