VOACANGINE
- CAS NO.：510-22-5
- Empirical Formula: C22H28N2O3
- Molecular Weight: 368.47
- MDL number: MFCD00077210
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-04-17 18:22:24
What is VOACANGINE?
Description
This alkaloid is of widespread occurrence, being found in Stemmadenia species and also is Vocanga africana, v. dregii and V. obtusa. It forms colourless needles when crystallized from MeOH and has [0'10 - 42° (c 1.0, CHCI3). It sublimes under vacuum at 135°CjO.01 mm and is readily soluble in CHC13 or Me2CO, but only sparingly so in EtOH or MeOH. Hydrolysis with KOH followed by acidification with HCl yields Ibogaine (q.v.).
The Uses of VOACANGINE
(-)-Voacangine is a bisindole alkaloid with ether-?a-?go-?go-?related gene channel blocker activity in vitro. hERG channel blocker.
What are the applications of Application
Voacangine is an indole alkaloid
Definition
ChEBI: (-)-voacangine is a monoterpenoid indole alkaloid with formula C22H28N2O3, isolated from several plant species. It has a role as an angiogenesis inhibitor, an antineoplastic agent and a plant metabolite. It is a monoterpenoid indole alkaloid, a tertiary amino compound, a methyl ester, an organic heteropentacyclic compound and an alkaloid ester. It is a conjugate base of a (-)-voacangine(1+).
References
lanot, Goutarel., Compt. rend., 241,986 (1955) Stauffacher, Seebeck., Helv. Chim. Acta, 41,169 (1958) Watts, Collera, Sandoval., Tetrahedron, 2, 173 (1958) Schuler, Verbeck, Warren.,J. Chern. Soc., 4776 (1958) Bartlett, Dickel, Taylor.,J. Amer. Chern. Soc., 80, 126 (1958) Renner, Prins, Stoll., Helv. Chim. Acta, 42,1572 (1959) Budzikiewicz etal., Bull. Soc. Chim. Fr., 1899 (1963)
Properties of VOACANGINE
| Melting point: | 223-224℃ (dec.) |
| Density | 1.25±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Store at -20°C,protect from light |
| solubility | DMF: 16 mg/ml; DMSO: 16 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
Safety information for VOACANGINE
Computed Descriptors for VOACANGINE
New Products
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