VJ115

CAS NO.：929256-79-1
Empirical Formula: C23H24N2O
Molecular Weight: 344.45
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 10:31:43

What is VJ115?

Description

VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cytoskeletal reorganization and angiogenesis.

Properties of VJ115

Boiling point:	593.0±50.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
pka	16.13±0.20(Predicted)

Safety information for VJ115

Computed Descriptors for VJ115

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