VINYL CHLOROFORMATE
Synonym(s):Vinyl chlorocarbonate;Vinyloxycarbonyl chloride
- CAS NO.：5130-24-5
- Empirical Formula: C3H3ClO2
- Molecular Weight: 106.51
- MDL number: MFCD00000641
- EINECS: 225-874-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is VINYL CHLOROFORMATE?
Chemical properties
clear colourless liquid
The Uses of VINYL CHLOROFORMATE
Vinyl Chloroformate was used to prepare analogues of the Nicotinic Acetylcholine Receptor Agonist (±)-UB-165. It was also used to synthesize possible antitumor agents such as paclitaxel-2''-carbonates and N-carbamyl triazenes.
Purification Methods
It has been fractionated through a Todd column (p 11, Model A with ~60 plates) under atmospheric pressure and the purity can be checked by gas chromatography. Stabilize it with 0.5% of 2,6-di-tert-butyl-p-cresol. It has IR with at 3100 + 2870 (CH2), 1780 (C=O), 1640 (C=C) and 940 (CH2out-of-plane) and 910 (CH2 wagging) cm-1. [IR: Lee J Org Chem 30 3943 1965, Levaillant Ann Chim (Paris) 6 504 1936.] It is used for protecting NH2 groups in peptide synthesis [Olofson et al. Tetrahedron Lett 1563 1977]. [Beilstein 3 III 28.]
Properties of VINYL CHLOROFORMATE
| Boiling point: | 68-69 °C735 mm Hg(lit.) |
| Density | 1.166 g/mL at 20 °C(lit.) |
| vapor pressure | 0.88 psi ( 20 °C) |
| refractive index | n |
| Flash point: | 24 °F |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Clear colorless |
| BRN | 1741679 |
Safety information for VINYL CHLOROFORMATE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H225:Flammable liquids H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for VINYL CHLOROFORMATE
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