VINBLASTINE (Vincaleukablastine)
- Empirical Formula: C46H58O9N4
- Molecular Weight: 0
What is VINBLASTINE (Vincaleukablastine)?
Description
A complex dimeric alkaloid occurring in Vinca rosea L., the base crystallizes from Et20 with one mole of solvent, m.p. 180-2°e. When crystallized from MeOH, the m.p. is 211-6°C. The alkaloid is dextrorotatory with [α]D + 42° and forms a dihydrochloride as the dihydrate, m.p. 244-6°C (dec.); the sulphate, m.p. 284-5°C; [α]26D- 28° (MeOH) and the diacetate, m.p. 168-1700 C; [α]D 26.4° (CHCL3).
Pharmacologically, the alkaloid has a marked antitumour activity and is active against certain leukaemias.
References
Neuss et aI., J. Amer. Chem. Soc., 81,4754 (1959) Neussetal., ibid, 84, 1509 (1962) Neuss et at., ibid, 86, 1440 (1964) Bommer, McMurray, Biemann., ibid, 86, 1439 (1964) Pharmacology: Noble, Beer, Cutts., Biochem. Pharmacal., 1,347 (1958)
Properties of VINBLASTINE (Vincaleukablastine)
| Melting point: | 210-1 0 C |
Safety information for VINBLASTINE (Vincaleukablastine)
Computed Descriptors for VINBLASTINE (Vincaleukablastine)
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