VICRIVIROC MALEATE
- CAS NO.：599179-03-0
- Empirical Formula: C32H42F3N5O6
- Molecular Weight: 649.7009896
- MDL number: MFCD09833218
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-26 13:56:28
What is VICRIVIROC MALEATE?
Description
Vicriviroc is a chemokine (C-C motif) receptor 5 (CCR5) antagonist (Ki = 2.5 nM). It selectively inhibits CCR5 over M1 and M2 muscarinic acetylcholine receptors (Kis = >10,000 nM for both) and human-ether-a-go-go (hERG) potassium channels (IC50 = 5.8 μM). Vicriviroc decreases chemotaxis induced by chemokine (C-C motif) ligand 3 (CCL3) in Ba/F3 cells expressing recombinant human CCR5 with an IC50 value of 0.91 nM. It inhibits the replication of 30 R5-tropic HIV-1 clinical isolates in peripheral blood mononuclear cells (PBMCs; EC50s = 0.04-1.4 nM) and reduces viral entry of seven drug-resistant strains of HIV-1 in U87 cells expressing CD4 and CCR5 (EC50s = 8.7-32.9 nM).
The Uses of VICRIVIROC MALEATE
Antiviral, CCR5 antagonist, treatment of autoimmune conditions.
Properties of VICRIVIROC MALEATE
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (76.96 mM; Need ultrasonic)H2O : 25 mg/mL (38.48 mM; Need ultrasonic and warming) |
| form | Powder |
| color | White to off-white |
Safety information for VICRIVIROC MALEATE
Computed Descriptors for VICRIVIROC MALEATE
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