VEEGUM

Toxicity

The LD50 in mice is considered to be >50000 mg/kg with oral suspensions of magnesium aluminum silicate . The dermal LD50 is considered to be >3.5 g/kg observed in rabbits. Magnesium aluminum silicate produced mild skin irritation. In a 90 day study in rats, animal fed a diet with 20% magnesium aluminum silicate had slightly stunted growth. With 5% and 10% the rats had increased silicone content in the spleen. At 2% one male rat died and at 10% one male and female rat died. These rats had fibrous exudates in the thorax and hemorrhage in the lungs with evidence of infection. No evidence of teratogenicity or mutagenicity was found in the appropriate studies.

Chemical properties

Granules.

The Uses of VEEGUM

antibiotic

The Uses of VEEGUM

water dispersible coating agent

The Uses of VEEGUM

magnesium aluminum silicate is a thickener with texturemodification and emulsion-stabilizing abilities, as well as astringent properties. This is refined and purified smectite clay. It is non-comedogenic and non-toxic.

Indications

Magnesium aluminum silicate is used as an over the counter antacid for the self-treatment of heartburn, sour stomach, or acid indigestion .

Background

Magnesium aluminum silicate is a naturally occurring mineral obtained from silicate ores of the montmorillonite group . It is refined to a powder for use in cosmetic and pharmaceutical applications as an absorbent, anticaking agent, opacifying agent, viscosity-increasing agent, suspending agent, tablet and capsule disintegrant, and tablet binder. It also has antacid properties and is used as a component of some over the counter antacid medications.

brand name

Veegum (Vanderbilt).

Pharmacokinetics

Magnesium aluminum silicate neutralizes excess acid in the stomach to reduce or eliminate symptoms of heartburn, sour stomach, or acid indigestion

Metabolism

Not Available