VALERENIC ACID

Synonym(s):(2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl- 1H-inden-4-yl]-2-methyl-2-propenoic acid

CAS NO.：3569-10-6
Empirical Formula: C15H22O2
Molecular Weight: 234.33
MDL number: MFCD00075694
EINECS: 203-677-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:17

What is VALERENIC ACID?

The Uses of VALERENIC ACID

Valerenic Acid, acts as a subtype-selective GABAA receptor agonist in neonatal rat brainstem preparations. It can be used for the synthesis of Valerena-4,7(11)-diene, a highly active sedative.

What are the applications of Application

Valerenic acid is a positive allosteric modulator of the GABAA receptor

Definition

ChEBI: A monocarboxylic acid that is 2-methylprop-2-enoic acid which is substituted at position 3 by a 3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl group. A bicyclic sesquiterpenoid constituent of the essential oil of the Valerian plant.

Biological Activity

Positive allosteric modulator of GABA A receptors that displays preference for receptors containing β 2 or β 3 subunits. Directly activates the receptor and also blocks the channel at high concentrations. Displays a sedative and anxiolytic activity in vivo . Also acts as a partial? agonist of 5-HT 5A receptors.

Properties of VALERENIC ACID

Melting point:	134-139°C
Boiling point:	374.5±21.0 °C(Predicted)
Density	1.06±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	Chloroform (Slightly), Ethanol (Slightly),Methanol (Slightly)
form	neat
pka	4.88±0.19(Predicted)
form	Solid
color	White to Off-White
BRN	3138020
CAS DataBase Reference	3569-10-6(CAS DataBase Reference)