valdetamide

Originator

Insomnia,ICN

Definition

ChEBI: Valdetamide is a fatty amide.

Manufacturing Process

1 kg of diethylacetonitrile dissolved in 3 litres of dry ether is gradually mixed in a reflex apparatus, while stirring and heating, with 400 g of potassium.
Thereupon evolution of hydrogen sets in and the potassium passes slowly into solution. After three hours any small amount of potassium, which may have remained unattacked is separated, and the solution is mixed with 1200 g of allyl bromide. The ether begins to boil and potassium bromide separates. The mass is heated for another hour, filtered, and the filtrate, after having distilled off the ether, is distilled in a vacuum. Thus diethylallylacetonitrile, distilling over at 78°C/9mm is obtained. By subsequent saponification with alcoholic potash the diethylallylacetamide is obtained. MP: 74°C.

Therapeutic Function

Hypnotic

Safety Profile

Poison to humans by ingestion. An experimental poison by ingestion, rectal, and intraperitoneal routes. Human systemic effects by ingestion: muscle spasms, cardiac arrhythmias, and respiratory depression. When heated to decomposition it emits toxic fumes of NOx