UUTHIAPDCFFQKQ-FOZLTFMXSA-N

Description

UR-144 N-pentanoic acid metabolite-d₅ is intended for use as an internal standard for the quantification of UR-144 N-pentanoic acid metabolite by GC- or LC-MS. UR-144 is a potent synthetic cannabinoid (CB) that preferentially binds the peripheral CB₂ receptor (K_i = 1.8 nM) over the central CB₁ receptor (K_i = 150 nM).¹ UR-144 N-pentanoic acid metabolite is an expected phase I metabolite of UR-144, based on the metabolism of similar cannabimimetics.^2,3 This metabolite should be detectable in either serum or urine.^2,3 The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.

References

1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB₂ cannabinoid receptor activity J. Med. Chem. 53(1),295-315(2010).
2. Wintermeyer, A., M?ller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010).
3. Chimalakonda, K.C., Moran, C.L., Kennedy, P.D., et al. Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine Anal. Chem. 83(16),6381-6388(2011).