USP7-IN-1

CAS NO.：1381291-36-6
Empirical Formula: C23H24ClN3O3
Molecular Weight: 425.91
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-22 18:57:36

What is USP7-IN-1?

Description

USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 77 μM, and can be used for the research of cancer. IC50: 77 μM (USP7)[1]

USP7-IN-1 (Example 2) is a selective and reversible inhibitor of USP7, with an IC50 of 77 μM, and shows no inhibition of USP8, USP5, Uch-L1, Uch-L3 or caspase 3. USP7-IN-1 inhibits the proliferation of HCT116 cells, with a GI50 of 67 μM[1].

References

[1]. SELECTIVE AND REVERSIBLE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7. WO 2013030218 A1

Properties of USP7-IN-1

Boiling point:	666.2±65.0 °C(Predicted)
Density	1.32±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: ≥ 40 mg/mL (93.92 mM)
form	Solid
pka	13.52±0.20(Predicted)
color	White to off-white

Safety information for USP7-IN-1

Computed Descriptors for USP7-IN-1

New Products

Dexamethasone Sodium Phosphate 2-(2-Ethoxyphenoxy)ethyl bromide 8-Bromo-7-(2-butynyl)-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 2-Fluoro-6-iodobenzoic acid 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate 1-Boc-4-cyanopiperidine 3-Pyridineacrylic acid Abiraterone Ethyl Ether Vardenafil Bis-sulphonamide(Dimer) 1-nitro-3,5-dimethyl adamantine (NMEM) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one 2-Amino-3,5-Dichloro-4-picoline 5-Amino-2-Ethoxypyridine