Urs-12-en-28-amide, 3-hydroxy-N-[2-[(2-hydroxyethyl)methylamino]-2-oxoethyl]-, (3β)-

CAS NO.：2416910-69-3
Empirical Formula: C35H58N2O4
Molecular Weight: 570.86
Update Date: 2026-04-24 14:58:40

What is Urs-12-en-28-amide, 3-hydroxy-N-[2-[(2-hydroxyethyl)methylamino]-2-oxoethyl]-, (3β)-?

Biological Activity

SENP1-IN-1 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 29. SENP1-IN-1 is developed for tumor radiosensitivity enhancement[1]. SENP1-IN-1 may improve the sensitivity of tumor cells to irradiation[1].SENP1-IN-1 (0.7-20 μM; 72 hours)has cytotoxic for Hella cells with an IC50 of >20μM[1].

References

[1]. Li, Yiliang, et al. Preparation of ursolic acid derivatives useful as SENP1 inhibitors and tumor radiosensitizer. CN110627860A.

Properties of Urs-12-en-28-amide, 3-hydroxy-N-[2-[(2-hydroxyethyl)methylamino]-2-oxoethyl]-, (3β)-

Boiling point:	705.8±60.0 °C(Predicted)
Density	1.12±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	14.41±0.10(Predicted)
color	White to off-white

Safety information for Urs-12-en-28-amide, 3-hydroxy-N-[2-[(2-hydroxyethyl)methylamino]-2-oxoethyl]-, (3β)-

Computed Descriptors for Urs-12-en-28-amide, 3-hydroxy-N-[2-[(2-hydroxyethyl)methylamino]-2-oxoethyl]-, (3β)-

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