Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-

CAS NO.：2387821-46-5
Empirical Formula: C15H9ClN4OS
Molecular Weight: 328.78
MDL number: MFCD34578507
Update Date: 2026-07-27 17:00:41

What is Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-?

Biological Activity

HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2]. HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1].HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1]. HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1].

References

[1]. Bellail AC, et, al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486. [2]. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1.

Properties of Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-

Density	1.51±0.1 g/cm3(Predicted)
pka	7.16±0.70(Predicted)
form	Solid
color	Light yellow to yellow

Safety information for Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-

Computed Descriptors for Urea, N-(3-chlorophenyl)-N'-(6-cyano-2-benzothiazolyl)-

New Products

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