UPGL00004
- CAS NO.：1890169-95-5
- Empirical Formula: C25H26N8O2S2
- Molecular Weight: 534.66
- Update Date: 2026-07-19 22:55:08
What is UPGL00004?
Biological Activity
UPGL00004 is a potent glutaminase C (GAC) inhibitor with IC50 of 29 nM, more selective for GAC than GLS2.
in vitro
Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab effectively inhibited triple-negative breast cancer cell growth and tumor growth.
in vivo
Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab inhibited tumor growth in a human xenograft model of breast cancer.
Properties of UPGL00004
| Density | 1.460±0.06 g/cm3(Predicted) |
| pka | 9.23±0.50(Predicted) |
| form | Solid |
| color | Off-white to gray |
Safety information for UPGL00004
Computed Descriptors for UPGL00004
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