UNIL-088
- CAS NO.：473545-11-8
- Empirical Formula: C73H128N13O22P
- Molecular Weight: 1570.87
- Update Date: 2023-03-31 09:12:58
What is UNIL-088?
Description
UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) designed for topical ocular delivery. The pro-moiety is grafted via an ester function to CsA and the solubilizing group is a phosphate ion. UNIL-088 can be rapidly hydrolysed under physiological conditions, and can retain a long shelf-life in aqueous media. UNIL-088 is more stable at pH 5 than at pH 7 with conversion rate constant of 3.2 x 10(-3) and 26.0 x 10(-3)days(-1), respectively.
Properties of UNIL-088
| Density | 1.108±0.06 g/cm3(Predicted) |
| pka | 1.81±0.10(Predicted) |
Safety information for UNIL-088
Computed Descriptors for UNIL-088
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