Unguisin A

CAS NO.：226956-06-5
Empirical Formula: C40H54N8O7
Molecular Weight: 758.90616
Update Date: 2026-04-24 14:59:07

What is Unguisin A?

Description

Unguisin A is a cyclic heptapeptide originally isolated from the marine fungus E. unguis whose structure is comprised of amino acids and GABA.¹ It binds to phosphate, pyrophosphate, and chloride but has no effect on chloride transport in a liposome-based assay.² It exhibited moderate antibacterial activity against S. aureus and V. parahaemolyticus in one assay but no activity against a variety of bacteria, including S. aureus, in another.^1,2

References

1. Malmstrom, J. Unguisins A and B: New cyclic peptides from the marine-derived fungus Emericella unguis J. Nat. Prod. 62(5),787-789(1999).
2. Ariawan, A.D., Webb, J.E.A., Howe, E.N.W., et al. Cyclic peptide unguisin A is an anion receptor with high affinity for phosphate and pyrophosphate Org. Biomol. Chem. 15(14),2962-2967(2017).

Properties of Unguisin A

Melting point:	105-115 °C
Boiling point:	1202.9±65.0 °C(Predicted)
Density	1.134±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form	A solid
pka	13.22±0.70(Predicted)

Safety information for Unguisin A

Computed Descriptors for Unguisin A

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