uncarine A
- CAS NO.：6899-73-6
- Empirical Formula: C21H24N2O4
- Molecular Weight: 368.43
- Update Date: 2025-04-17 18:22:24
What is uncarine A?
Description
This amorphous alkaloid was first isolated from Uncaria kawakamii, subsequently being found in other Uncaria species and also in Ourouparia formosan a Matsumara. The base is dextrorotatory having [α]D + 106.5° and gives a hydrochloride hemihydrate as colourless needles, m.p. 231°C (dec.) and the N-acetyl derivative, m.p. 165°C. The stereochemistry of this alkaloid has been revised comparatively recently.
Definition
ChEBI: Uncarine A is a member of indolizines.
References
Raymond-Hamet., Compt. rend., 203, 1383 (1936)
Kondo, Ikeda.,]. Pharm. Soc., Japan, 61,416,453 (1941)
Kondo, Ikeda., ibid, 62, 15 (1942)
Raymond-Hamet., Compt. rend., 230, 1405 (1950)
Kondo, Nozoye, Tobita., Chern. Abstr., 49, 15921 (1955)
Raymond-Hamet., Compt. rend., 245, 1458 (1957)
Hendrickson., J. Amer. Chern. Soc., 84,650 (1962)
Revised stereochemistry:
Shamma et ai., J. Amer. Chern. Soc., 89, 1739 (1967)
Beecham et ai., Chern. Commun., 535 (1967)
Properties of uncarine A
| Melting point: | 120-130°C |
| Boiling point: | 555.2±50.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| pka | 13.56±0.60(Predicted) |
Safety information for uncarine A
Computed Descriptors for uncarine A
New Products
2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 2,4-Dihydroxybenzaldehyde Dipropyl disulfide Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Obidoxime hydrochloride API 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 2-Pentyn-1-oL 4-NitrobenzotrifluorideRelated products of tetrahydrofuran
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