UNC 669
- CAS NO.：1314241-44-5
- Empirical Formula: C15H20BrN3O
- Molecular Weight: 338.24
- MDL number: MFCD26936345
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 23:13:44
What is UNC 669?
The Uses of UNC 669
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT).
Definition
ChEBI: (5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is an aromatic carboxylic acid and a pyridinemonocarboxylic acid.
Biological Activity
unc 669 is a potent antagonist of l3mbtl1 (ic50=4.2 μm) and l3mbtl3 (ic50=3.1 μm).there is less bio-data supported for unc669. unc1679 is an analog of unc669. unc1215 is the first potent and selective antagonism of a methyl-lysine reader protein, l3mbtl3, which antagonizes the mono- and dimethyl-lysine reading function of l3mbtl3. [1]lysine methylation is a key epigenetic landmark, the dysregulation of which is related to many diseases. unc1679 maintains in vitro and cellular potency with improved selectivity against other mbt-containing proteins. the antagonists described were also found to effectively interact with unlabeled endogenous l3mbtl3 in cells. [1]
References
1. james li, korboukh vk, krichevsky l et al. small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for l3mbtl3. j med chem. 2013 sep 26;56(18):7358-71. doi: 10.1021/jm400919p. epub 2013 sep 16.
Properties of UNC 669
| Boiling point: | 458.0±45.0 °C(Predicted) |
| Density | 1.424±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20° C |
| solubility | insoluble in H2O; ≥52.4 mg/mL in EtOH with ultrasonic; ≥9.35 mg/mL in DMSO |
| form | solid |
| pka | 9.78±0.20(Predicted) |
| color | White to off-white |
Safety information for UNC 669
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for UNC 669
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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