PFI-1
Synonym(s):2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-bezenesulfonamide;PF-06405761
- CAS NO.：1403764-72-6
- Empirical Formula: C16H17N3O4S
- Molecular Weight: 347.39
- MDL number: MFCD22580416
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-05 14:33:18
What is PFI-1?
Description
PFI 1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). PFI 1 induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). PFI 1 also downregulates Aurora B expression in MV4;11 cells.
The Uses of PFI-1
PFI-1 is used as a selective protein interaction inhibitor targetting BET bromodomains, used as regulators required for efficient expression of several growth promoting and anti-apoptotic genes.
What are the applications of Application
PFI-1 is An epigenetic chemical probe.
Definition
ChEBI: 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide is a member of quinazolines.
Storage
Store at RT
Properties of PFI-1
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | white to beige |
Safety information for PFI-1
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PFI-1
New Products
(E)-1-Ethoxyethene-2-boronic Acid Pinacol Ester 1,3-Diethyl-1,3-Diphenylurea 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,4-dihydroxybenzaldehyde 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 3-Hydroxy-4-nitrobromobenzene 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Thio AcetamideRelated products of tetrahydrofuran
You may like
-
PF-06405761 >95% CAS 1403764-72-6View Details
1403764-72-6 -
PFI-1 98.00% CAS 1403764-72-6View Details
1403764-72-6 -
PFI-1 >95% CAS 1403764-72-6View Details
1403764-72-6 -
PFI-1 CAS 1403764-72-6View Details
1403764-72-6 -
2-Ethyl-1,4-diaminobenzene 98%View Details
MFCD19203885 -
2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 98%View Details
-
Hot Sales:Thio AcetamideView Details
62-55-5 -
CosmoticsView Details
26218-04-2
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.