PFI-1
Synonym(s):2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-bezenesulfonamide;PF-06405761
- CAS NO.：1403764-72-6
- Empirical Formula: C16H17N3O4S
- Molecular Weight: 347.39
- MDL number: MFCD22580416
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:17:03
What is PFI-1?
Description
PFI 1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). PFI 1 induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). PFI 1 also downregulates Aurora B expression in MV4;11 cells.
The Uses of PFI-1
PFI-1 is used as a selective protein interaction inhibitor targetting BET bromodomains, used as regulators required for efficient expression of several growth promoting and anti-apoptotic genes.
What are the applications of Application
PFI-1 is An epigenetic chemical probe.
Definition
ChEBI: 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide is a member of quinazolines.
Storage
Store at RT
Properties of PFI-1
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | white to beige |
Safety information for PFI-1
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PFI-1
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