UK-371804
- CAS NO.：256477-09-5
- Empirical Formula: C14H16ClN5O4S
- Molecular Weight: 385.83
- MDL number: MFCD30749185
- Update Date: 2026-01-13 15:16:37
What is UK-371804?
Description
UK-371804 is a potent and selectiveurokinase-type plasmogen activator (uPA)inhibitor. It has excellent selectivityover tPA, plasmin, Factor IXa and Xa.In vitro, it is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound modelfollowing topical delivery, it is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. It has the potential for the treatment of chronic dermal ulcers.
References
http://www.dcchemicals.com/product_show-UK_371804.html
http://adisinsight.springer.com/drugs/800026963
Fish, P. V., et al. "Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. "Journal of Medicinal Chemistry 50.10(2007):2341.
Properties of UK-371804
| storage temp. | Store at -20°C |
| solubility | DMSO:5.0(Max Conc. mg/mL);2.59(Max Conc. mM) |
| form | A crystalline solid |
| color | White to off-white |
| CAS DataBase Reference | 256477-09-5 |
Safety information for UK-371804
Computed Descriptors for UK-371804
New Products
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