UDP-ALPHA-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT

Chemical properties

White to off-white crystalline powder

The Uses of UDP-ALPHA-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT

Uridine-5'-diphospho-N-acetylglucosamine sodium salt is used as a chemical reagent in studies relating to the synthesis of immunogens.

The Uses of UDP-ALPHA-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT

GlcNAc transferase substrate

The Uses of UDP-ALPHA-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT

Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) sodium salt has been used:

• as a component of reaction cocktail in endoplasmic reticulum to Golgi transport assay
• as a reference standard for the quantification of UDP-GlcNAc in liver tissues using high-performance liquid chromatography (HPLC)
• in testing the glycosylation activity of O-GlcNAc transferase (OGT) against peptide substrate

What are the applications of Application

UDP-N-acetyl-D-glucosamine disodium salt is a nucleotide sugar and donor substrate for O-GlcNAc transferase.

General Description

Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) is a nucleotide sugar. It is synthesized from glucose via the hexosamine biosynthetic pathway (HBP). UDP-GlcNAc is transported actively into Golgi, nucleotide sugar transporter (NST). The levels of UDP-GlcNAc is modulated by the concentration of nutrients exposed to the cell.

Biochem/physiol Actions

Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) is a sugar donor and aids in the endomembrane glycosylation of endoplasmic reticulum and Golgi. The decreased levels of UDP-GlcNAc has an influence on the normal cellular proliferation and apoptosis. UDP-GlcNAc elicits feedback inhibition of the enzyme glutamine:fructose-6-phosphate amidotransferase (GFAT).