UCSF924
- CAS NO.：1434515-70-4
- Empirical Formula: C20H22N2O2
- Molecular Weight: 322.4
- MDL number: MFCD31697726
- Update Date: 2026-01-13 11:25:38
What is UCSF924?
Description
UCSF924 is a selective, high-affinity dopamine D4 receptor (DRD4) partial agonist (Ki = 3 nM for human D4) with a 7.4-fold bias toward arrestin recruitment over Gαi (Gαi/0; Gi/G0) signaling activation with respect to quinpirole. UCSF924 exhibits no detectable affinity for D2, D3 or the F261V/L328F D4 mutant and no agonist activity toward a panel of 320 nonolfactory GPCRs even at a high concentration of 1 μM. The UCSF924 structure analog UCSF924NC is the recommended negative control compound with a 1/2500-fold reduced D4 affinity.
Properties of UCSF924
| Boiling point: | 522.5±50.0 °C(Predicted) |
| Density | 1.174±0.06 g/cm3(Predicted) |
| solubility | DMSO:40.0(Max Conc. mg/mL);124.0(Max Conc. mM) |
| pka | 4.08±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for UCSF924
Computed Descriptors for UCSF924
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