UCSF924

CAS NO.：1434515-70-4
Empirical Formula: C20H22N2O2
Molecular Weight: 322.4
MDL number: MFCD31697726
Update Date: 2026-07-22 15:57:46

What is UCSF924?

Description

UCSF924 is a selective, high-affinity dopamine D4 receptor (DRD4) partial agonist (Ki = 3 nM for human D4) with a 7.4-fold bias toward arrestin recruitment over Gαi (Gαi/0; Gi/G0) signaling activation with respect to quinpirole. UCSF924 exhibits no detectable affinity for D2, D3 or the F261V/L328F D4 mutant and no agonist activity toward a panel of 320 nonolfactory GPCRs even at a high concentration of 1 μM. The UCSF924 structure analog UCSF924NC is the recommended negative control compound with a 1/2500-fold reduced D4 affinity.

Properties of UCSF924

Boiling point:	522.5±50.0 °C(Predicted)
Density	1.174±0.06 g/cm3(Predicted)
solubility	DMSO:40.0(Max Conc. mg/mL);124.0(Max Conc. mM)
pka	4.08±0.40(Predicted)
form	Solid
color	White to off-white

Safety information for UCSF924

Computed Descriptors for UCSF924

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