UBCS039

CAS NO.：358721-70-7
Empirical Formula: C16H13N3
Molecular Weight: 247.29
MDL number: MFCD00206184
Update Date: 2026-04-21 10:31:43

What is UBCS039?

Biological Activity

UBCS039, the first synthetic SIRT6 activator with EC50 of 38 μM, induces time-dependent activation of autophagy in multiple human tumor cell lines.

in vitro

UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells. It leads to autophagosome accumulation in human cancer cells.UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation.

Western Blot Analysis

Cell Line:	Human H1299 cells.
Concentration:	75 μM.
Incubation Time:	48 and 72 hours.
Result:	Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.

Cell Proliferation Assay

Cell Line:	Human H1299 cells.
Concentration:	100 μM.
Incubation Time:	48 and 72 hours.
Result:	Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.

Properties of UBCS039

Boiling point:	453.9±45.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO : 125 mg/mL (505.48 mM)
form	Solid
pka	4.66±0.12(Predicted)
color	Light yellow to yellow

Safety information for UBCS039

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for UBCS039

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