Tygacil

Synonym(s):9-t-Butylglycylamido-minocycline hydrate;TBG-MINO;Tigecyclin;Tygacil

CAS NO.：1229002-07-6
Empirical Formula: C29H41N5O9
Molecular Weight: 603.67
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:34:14

What is Tygacil?

The Uses of Tygacil

Tigecycline hydrate, a glycylcycline antibiotic, used to treat infection by drug resistant bacteria such as Staphylococcus aureus (Staph aureus) and Acinetobacter baumannii.

General Description

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.

Biochem/physiol Actions

Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.

Properties of Tygacil

storage temp.	2-8°C
solubility	DMSO: ≥3mg/mL (warmed)
form	powder
color	off-white to yellow-brown
optical activity	[α]/D -160 to 170°, c = 0.15 in methanol

Safety information for Tygacil

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H319:Serious eye damage/eye irritation H360:Reproductive toxicity
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Tygacil

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