TW-37
- CAS NO.：877877-35-5
- Empirical Formula: C33H35NO6S
- Molecular Weight: 573.7
- MDL number: MFCD17010275
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 17:25:46
What is TW-37?
Description
TW-37 is an inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively). It induces apoptosis, inhibits migration and capillary sprouting, and blocks the expression of the angiogenic chemokines CXCL1 and CXCL8 in endothelial cells. TW-37 decreases the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis when administered intravenously. It has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells.
The Uses of TW-37
TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively.
The Uses of TW-37
TW-37 is a Bcl-2 inhibitor that suppresses growth and enhance cisplatin-induced apoptosis in ovarian cancer cells. Also functions as an MCL-1 inhibitor that kills many more malignant cells.
What are the applications of Application
TW-37 is a Bcl-2 inhibitor that inhibits the angiogenesis of endothelial cells
Definition
ChEBI: N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide is a member of benzamides.
Properties of TW-37
| Boiling point: | 723.7±60.0 °C(Predicted) |
| Density | 1.280 |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥19.75 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with gentle warming and ultrasonic |
| pka | 7.86±0.50(Predicted) |
| form | A crystalline solid |
| color | White to off-white |
Safety information for TW-37
Computed Descriptors for TW-37
New Products
AMino-(3-Methylphenyl)-acetic acid 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-Boc-3-(cyanomethyl)azetidine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 4, 4'-Ditolylamine (or) 4,4-Dimethyl Diphenylamine 2-Bromo-5-Chloropyridine 2-Picolinic acid N-oxide 4-Butyl Resorcinol 2-(2,4-Diaminophenoxy)ethanol Dihydrochloride 5-Bromo-2-Hydroxy-3-Nitro Pyridine 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside 4-Pentyn-1-ol 2-Bromo-6-fluoroaniline 5-fluoro-1,3-benzodioxole 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 2-(Chloromethyl) quinazolin-4(3H)-one 4-Chloro-2-methyl quinoline 2-Amino-4-phenyl-thiazoleRelated products of tetrahydrofuran
You may like
-
![N-{4-[(2-tert-butylbenzene)sulfonyl]phenyl}-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide 95% CAS 877877-35-5](https://img.chemicalbook.in//Content/image/CP5.jpg)
N-{4-[(2-tert-butylbenzene)sulfonyl]phenyl}-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide 95% CAS 877877-35-5View Details
877877-35-5 -
142253-58-5 1-Boc-3-(cyanomethyl)azetidine 98+View Details
142253-58-5 -
142253-58-5 1-Boc-3-(cyanomethyl)azetidine 98+View Details
142253-58-5 -
898271-20-0 98+View Details
898271-20-0 -
Dimedone 98+View Details
126-81-8 -
142253-58-5 1-Boc-3-(cyanomethyl)azetidine 98+View Details
142253-58-5 -
898271-20-0 98+View Details
898271-20-0 -
Dimedone 98+View Details
126-81-8