TRIS(DIETHYLAMINO)PHOSPHINE
Synonym(s):Hexaethylphosphorous triamide;Tris(N,N-diethylamino)phosphine;Hexaethyltriamidophosphite;Hexaethyltriaminophosphine;Phosphorous acid tris(diethylamide)
- CAS NO.：2283-11-6
- Empirical Formula: C12H30N3P
- Molecular Weight: 247.36
- MDL number: MFCD00009041
- EINECS: 218-920-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:01
What is TRIS(DIETHYLAMINO)PHOSPHINE?
Chemical properties
clear colorless to yellow-orange liquid
The Uses of TRIS(DIETHYLAMINO)PHOSPHINE
Tris(diethylamino)phosphine [(Et2N)3P] can be used as a reagent to synthesize:
- 1,1′-Dialkylisoindigo derivatives by reacting with various 1-alkylisatins via deoxygenation reaction.
- 1-Aminomethylisatins by treating with isatin and primary and secondary amines.
It can also be used in the deoxygenation of some cyclic α-diketones using fullerene C60.
The Uses of TRIS(DIETHYLAMINO)PHOSPHINE
suzuki reaction
Properties of TRIS(DIETHYLAMINO)PHOSPHINE
| Melting point: | 230-232 °C |
| Boiling point: | 80-90 °C10 mm Hg(lit.) |
| Density | 0.903 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 58 °C |
| storage temp. | Store below +30°C. |
| form | Liquid |
| pka | 9.74±0.70(Predicted) |
| Specific Gravity | 0.903 |
| color | Clear colorless to yellow-orange |
| Water Solubility | Insoluble in water. |
| Sensitive | Air Sensitive |
| BRN | 636187 |
| CAS DataBase Reference | 2283-11-6(CAS DataBase Reference) |
| EPA Substance Registry System | Phosphorous triamide, hexaethyl- (2283-11-6) |
Safety information for TRIS(DIETHYLAMINO)PHOSPHINE
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for TRIS(DIETHYLAMINO)PHOSPHINE
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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