Tris(2-aminoethyl)amine
Synonym(s):2,2′,2′′-Nitrilotriethylamine;2,2′,2′′-Triaminotriethylamine;TAEA
- CAS NO.：4097-89-6
- Empirical Formula: C6H18N4
- Molecular Weight: 146.23
- MDL number: MFCD00008177
- EINECS: 223-857-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:15
What is Tris(2-aminoethyl)amine?
Chemical properties
Colorless liquid
The Uses of Tris(2-aminoethyl)amine
Tris(2-aminoethyl)amine is a tetradentate chelating ligand and forms stable complexes with transition metals. It is also used as a carbon dioxide absorbent. Further, it acts as a reagent for cleavage of the fluorenylmethyloxycarbonyl (Fmoc) group in peptide synthesis. It reacts with aryl isocyanates and isothiocyanates to give tris-urea and -thiourea derivatives.
Definition
ChEBI: Tris(2-aminoethyl)amine is a tetramine.
General Description
Tris(2-aminoethyl)amine (TREN) is a water soluble tripodal ligand that is majorly used in co-ordination chemistry. It has three aminoethylgroups that attach with the surface atoms to provide a scaffold assembly.
Hazard
A poison by ingestion and skin contact.
Safety Profile
A poison by ingestion and skin contact. When heated to decomposition it emits toxic vapors of NOx.
Purification Methods
For a separation from a mixture containing 62% TRIEN, see entry under triethylenetetramine. Also purify it by conversion to the hydrochloride (see below), recrystallise it and regenerate the free base [Xie & Hendrickson J Am Chem Soc 109 6981 1987]. [Beilstein 4 H 256, 4 II 695, 4 III 545, 4 IV 1250.]
Properties of Tris(2-aminoethyl)amine
| Melting point: | -16 °C |
| Boiling point: | 114 °C/15 mmHg (lit.) |
| Density | 0.976 g/mL at 20 °C (lit.) |
| vapor density | 5 (vs air) |
| vapor pressure | 0.02 mm Hg ( 20 °C) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Sparingly), DMSO (Slightly) |
| form | saline suspension |
| pka | 10.00±0.10(Predicted) |
| color | Clear yellow |
| Specific Gravity | 0.977 |
| Water Solubility | Miscible with water. |
| Sensitive | Hygroscopic |
| BRN | 1739626 |
| Stability: | Stable. Hygroscopic. Absorbs carbon dioxide from the air. Incompatible with strong acids, strong oxidizing agents. |
| CAS DataBase Reference | 4097-89-6(CAS DataBase Reference) |
| EPA Substance Registry System | 1,2-Ethanediamine, N,N-bis(2-aminoethyl)- (4097-89-6) |
Safety information for Tris(2-aminoethyl)amine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H310:Acute toxicity,dermal H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tris(2-aminoethyl)amine
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