Trimethoprim-d3
- CAS NO.：1189923-38-3
- Empirical Formula: C14H18N4O3
- Molecular Weight: 290.31772
- MDL number: MFCD16039497
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-20 16:56:20
What is Trimethoprim-d3?
Description
Trimethoprim-d3 is intended for use as an internal standard for the quantification of trimethoprim by GC- or LC-MS. Trimethoprim is a synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), which is necessary for the synthesis of purines, amino acids, and thymidylic acid. Trimethoprim shows prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively). Formulations containing trimethoprim, commonly used in combination with sulfamethoxazole to minimize acquired resistance, have been used in the treatment of urinary tract infections.
Chemical properties
Off-White to Pale Yellow Solid
The Uses of Trimethoprim-d3
Trimethoprim-d3 (Major) is an antibacterial.
The Uses of Trimethoprim-d3
Deuterated Trimethoprim, an antibacterial
What are the applications of Application
Trimethoprim-d3 is a deuterated Trimethoprim
Properties of Trimethoprim-d3
| Melting point: | 208-210°C |
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Pale Yellow |
Safety information for Trimethoprim-d3
Computed Descriptors for Trimethoprim-d3
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