Trimetazidine dihydrochloride
Synonym(s):Trimetazidine dihydrochloride
- CAS NO.：13171-25-0
- Empirical Formula: C14H24Cl2N2O3
- Molecular Weight: 339.26
- MDL number: MFCD00243086
- EINECS: 236-117-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:23:26
What is Trimetazidine dihydrochloride ?
Description
Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC50 = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.
Chemical properties
Crystalline Solid
The Uses of Trimetazidine dihydrochloride
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:
- Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
- Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.
The Uses of Trimetazidine dihydrochloride
Coronary vasodilator. Antianginal
The Uses of Trimetazidine dihydrochloride
Antianoxic
What are the applications of Application
Trimetazidine Dihydrochloride is an antianginal and coronary vasodilator
Definition
ChEBI: Trimetazidine hydrochloride is an aromatic amine.
Properties of Trimetazidine dihydrochloride
| Melting point: | 231-235 °C(lit.) |
| storage temp. | Refrigerator |
| solubility | Freely soluble in water, sparingly soluble in alcohol. |
| form | neat |
| form | Solid |
| color | White to Off-White |
| Merck | 14,9705 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 13171-25-0(CAS DataBase Reference) |
Safety information for Trimetazidine dihydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Trimetazidine dihydrochloride
| InChIKey | XIRALXKCBGTYSC-UHFFFAOYSA-N |
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