TRIISOBUTYLAMINE

CAS NO.：1116-40-1
Empirical Formula: C12H27N
Molecular Weight: 185.35
MDL number: MFCD00040501
EINECS: 214-236-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:27:05

What is TRIISOBUTYLAMINE?

Chemical properties

Triisobutylamine is flammable.

The Uses of TRIISOBUTYLAMINE

Triisobutylamine is suitable to develop second generation ionic liquid matrices for MALDI-MS of peptides, proteins and carbohydrates. It may be used in the separation of cis-fatty acid salts and and trans-fatty acid (elaidic acid) salts using a new organic solvent nanofiltration membrane based on polydicyclopentadiene. It may be used as base in the synthesis of acroyl ammonium derivatives.

What are the applications of Application

Triisobutylamine is suitable to develop second generation ionic liquid matrices for MALDI-MS of peptides, proteins and carbohydrates

Production Methods

Triisobutylamine is manufactured from isobutanol and ammonia under heat and pressure.

General Description

Clear pale yellow liquid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

TRIISOBUTYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic.

Fire Hazard

TRIISOBUTYLAMINE is combustible.

Properties of TRIISOBUTYLAMINE

Melting point:	-21.8°C
Boiling point:	192-193 °C/770 mmHg (lit.)
Density	0.766 g/mL at 25 °C (lit.)
refractive index	n20/D 1.423(lit.)
Flash point:	135 °F
form	clear liquid
pka	pK1:10.42(+1) (25°C)
color	Colorless to Almost colorless
BRN	1698950
EPA Substance Registry System	Triisobutylamine (1116-40-1)

Safety information for TRIISOBUTYLAMINE

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H226:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.