TRIHEPTANOIN

Absorption

A single 0.3 g/kg dose of triheptanoin reaches a Cmax of 178.9 μmol/L, with a Tmax 0.5 h, and an AUC of 336.5 μmol*h/L. A single 0.4 g/kg dose of triheptanoin reaches a Cmax of 259.1 μmol/L, with a Tmax 0.8 h, and an AUC of 569.1 μmol*h/L.

Chemical properties

colourless liquid

The Uses of TRIHEPTANOIN

triheptanoin is a triglyceride that acts as a surfactant and skinconditioning agent, it also helps increase product viscosity. often used in cleansers, face and neck products, moisturizers and lipsticks.

Indications

Triheptanoin is a medium chain triglyceride indicated to provide calories and fatty acids to treat long chain fatty acid oxidation disorders (lc-FAODs).

Background

Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation. In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, rhabdomyolysis, and hepatomegaly. Complications in lc-FAOD patients are reduced from approximately 60% to approximately 10% with the addition of triheptanoin.
Triheptanoin was granted FDA approval on 30 June 2020.

Flammability and Explosibility

Non flammable

Pharmacokinetics

Triheptanoin is a source of medium chain fatty acids for patients with lc-FAODs. It has a moderate duration of action and a wide therapeutic window. Patients should be counselled regarding the risk of feeding tube dysfunction and intestinal malabsorption due to pancreatic insufficiency.

Metabolism

Triheptanoin is hydrolysed to heptanoate, which can be further metabolized to β-hydroxypentanoate or β-hydroxybutyrate.