TRIETHYL 4-PHOSPHONOCROTONATE
Synonym(s):4-(Diethoxyphosphinyl)-2-butenoic acid ethyl ester;4-Phosphonocrotonic acid triethyl ester
- CAS NO.：10236-14-3
- Empirical Formula: C10H19O5P
- Molecular Weight: 250.23
- MDL number: MFCD00009192
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-16 09:55:31
What is TRIETHYL 4-PHOSPHONOCROTONATE?
Chemical properties
CLEAR LIGHT YELLOW LIQUID
The Uses of TRIETHYL 4-PHOSPHONOCROTONATE
Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.
The Uses of TRIETHYL 4-PHOSPHONOCROTONATE
Reactant for:
- Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase
- Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions
- Orally bioavailable GPR40 agonist synthesis
- Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
- Preaparation of mGlu4R agonists
- Dearomatizing cyclization of nicotinyl-substituted esters and ketones
What are the applications of Application
Triethyl 4-phosphonocrotonate, mixture of isomers is used for mGlu4R agonist preparation
Properties of TRIETHYL 4-PHOSPHONOCROTONATE
| Boiling point: | 135 °C0.4 mm Hg(lit.) |
| Density | 1.128 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| form | Liquid |
| color | Clear light yellow |
| CAS DataBase Reference | 10236-14-3(CAS DataBase Reference) |
Safety information for TRIETHYL 4-PHOSPHONOCROTONATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for TRIETHYL 4-PHOSPHONOCROTONATE
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