Toloxatone
Synonym(s):5-(Hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone;Humoryl
- CAS NO.：29218-27-7
- Empirical Formula: C11H13NO3
- Molecular Weight: 207.23
- MDL number: MFCD00865391
- EINECS: 249-522-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:29:06
What is Toloxatone?
Description
Toloxatone is a selective, reversible and competitive inhibitor of type A monoamine oxidase (MAO-A) which shows clinical utility as an antidepressant. It is reportedly free of the "cheese effect" in man, possibly due to the reversible nature of its inhibitory effect on intestinal MAO-A in the presence of high concentrations of tyramine.
Originator
Delalande (France)
The Uses of Toloxatone
Toloxatone is a monoamine oxidase-A (MAO-A) inhibitor.
Definition
ChEBI: 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one is a member of the class of oxazolidinones that is 5-(hydroxymethyl)-1,3-oxazolidin-2-one substituted by a 3-methylphenyl group at position 3. It is a member of toluenes, an oxazolidinone and a primary alcohol.
brand name
HUMORYL
Properties of Toloxatone
| Melting point: | 76° |
| Boiling point: | 358.9±21.0 °C(Predicted) |
| Density | 1.245±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: >10mg/mL |
| form | solid |
| pka | 14.05±0.10(Predicted) |
| color | White to off-white |
Safety information for Toloxatone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Toloxatone
New Products
3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 1-Boc-3-(cyanomethyl)azetidine Dimedone 1-N-Boc-3-(aminoethyl)azetidine N-BOC-piperidine-4-carboxylic acid 4,6-Dichlororesorcinol 5-Amino-2-Bromo-3-Chloropyridine 2-Picolinic acid N-oxide 4-Butyl Resorcinol 2-Bromo-5-Chloropyridine 5-Bromo-2-Hydroxy-3-Nitro Pyridine 2-Amino-4-phenyl-thiazole N-(4-Bromophenyl)-2-chloroacetamide TRIFLOURO ACETICACID-D METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3Related products of tetrahydrofuran
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