Tolimidone
Synonym(s):5-(3-Methylphenoxy)- 2(1H)-pyrimidinone;CP 26154;NSC 314335;Tolimidone
- CAS NO.：41964-07-2
- Empirical Formula: C11H10N2O2
- Molecular Weight: 202.21
- MDL number: MFCD00866900
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 19:14:41
What is Tolimidone?
Description
MLR-1023 is an allosteric activator of Lyn kinase (EC50 = 63 nM). It has no significant activity against a panel of related kinases. MLR-1023 is orally bioavailable and reduces blood glucose levels in mice subjected to an oral glucose tolerance test. This effect is insulin-dependent, with MLR-1023 increasing insulin receptor sensitivity. MLR-1023 produces a dose-dependent and durable glucose-lowering effect in chronically treated db/db mice without causing weight gain.
The Uses of Tolimidone
Tolimidone (MLR-1023) is an allosteric Lyn kinase activator that has been shown to reduce blood glucose levels in mice. Studies show that Tolimidone is an effective insulin receptor-potentiating agent that is potentially capable of producing durable blood glucose-lowering activity in diabetics. Tolimidone is a candidate for the treatment of type 2 diabetes.
The Uses of Tolimidone
Tolimidone (MLR-1023) is an allosteric Lyn kinase activator that has been shown to reduce blood glucose levels in mice. Studies show that Tolimidone is an effective insulin receptor-potentiating agent that is potentially capable of producing durable blood glucose-lowering activity in diabetics. Tolimidone is a candidate for the treatment of type 2 diabetes.
Storage
Store at +4°C
Properties of Tolimidone
| Melting point: | 163-164℃ |
| Density | 1.22 |
| storage temp. | room temp |
| solubility | DMSO: soluble15mg/mL (clear solution) |
| form | powder |
| pka | 8.14±0.10(Predicted) |
| color | white to beige |
Safety information for Tolimidone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tolimidone
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