Tolbutamide-d9
- CAS NO.：1219794-57-6
- Empirical Formula: C12H18N2O3S
- Molecular Weight: 270.35
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-11-04 17:01:59
What is Tolbutamide-d9?
Description
Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 μM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes.
Chemical properties
White Solid
The Uses of Tolbutamide-d9
Labelled Tolbutamide (T535150). An antidiabetic, used as a hypoglycemic agent in veterinary medicine.
Properties of Tolbutamide-d9
| Melting point: | 108-111°C |
| storage temp. | Refrigerator |
| solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml |
| form | A solid |
| color | White to off-white |
Safety information for Tolbutamide-d9
Computed Descriptors for Tolbutamide-d9
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