4-Hydroxytolbutamide

Synonym(s):N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide

CAS NO.：5719-85-7
Empirical Formula: C12H18N2O4S
Molecular Weight: 286.35
MDL number: MFCD00144466
EINECS: 200-835-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-03-13 23:13:44

What is 4-Hydroxytolbutamide?

Description

4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs.

Chemical properties

White Solid

The Uses of 4-Hydroxytolbutamide

4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.

The Uses of 4-Hydroxytolbutamide

A metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes

What are the applications of Application

Hydroxy Tolbutamide is a P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker.

Definition

ChEBI: A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.

Properties of 4-Hydroxytolbutamide

Melting point:	100-102 °C
Density	1.268±0.06 g/cm3(Predicted)
Flash point:	2℃
storage temp.	2-8°C
solubility	ethanol: 12 mg/mL
form	Solid
pka	4.96±0.10(Predicted)
color	white

Safety information for 4-Hydroxytolbutamide

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P235:Store in a well-ventilated place. Keep cool.