TOFISOPAM

Synonym(s):7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine;EGYT 341;Seriel

CAS NO.：22345-47-7
Empirical Formula: C22H26N2O4
Molecular Weight: 382.45
MDL number: MFCD00823171
EINECS: 244-922-3
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is TOFISOPAM?

Originator

Grandaxine,Ozothine,France,1975

The Uses of TOFISOPAM

Tofisopam is a reagent used in preparation of allosteric ligands for pharmacological dark receptors GPR68 and GPR65. An anticonvulsant.

What are the applications of Application

Tofisopam is a GABAA receptor ligand and modulator

Definition

ChEBI: Tofisopam is an organic molecular entity.

Manufacturing Process

A mixture of 38.6 g (0.1 mol) of 3,4,3',4'-tetramethoxy-6-(α-acetopropyl)- benzophenone, 5.5 g (0.11 mol) of 100% hydrazine hydrate or 3.52 g (0.11 mol) of hydrazine, and 500 ml of absolute ethanol is boiled for 5 hours. After adding 100 ml of benzene, 400 ml of solvent mixture is distilled off from the reaction mixture by slow boiling for 3 hours. After cooling for 8 hours, 19 g of 5H-2,3-benzodiazepine derivative are separated from the residue as small, white crystals. The melting point is 133°C to 136°C (after recrystallizing from absolute ethanol, 136°C)

Therapeutic Function

Tranquilizer

Properties of TOFISOPAM

Melting point:	155-159°C
Boiling point:	509.61°C (rough estimate)
Density	1.2098 (rough estimate)
refractive index	1.6500 (estimate)
solubility	DMSO: ~14 mg/mL
form	solid
pka	7.29±0.40(Predicted)
color	white
λmax	310nm(MeOH)(lit.)
Merck	14,9503
Stability:	Hygroscopic

Safety information for TOFISOPAM

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P273:Avoid release to the environment.