TM 5275

Synonym(s):2-[2-[2-(4-Benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetamido]-5-chlorobenzoic acid sodium salt;5-Chloro--[[2-[2-[4-(diphenylmethyl)-1-piperazinyl]-2-oxoethoxy]acetyl]amino]-benzoic acid sodium salt;Sodium 5-chloro-2-[({2-[4-(diphenylmethyl) piperazin-1-yl]-2-oxoethoxy}acetyl)amino]benzoate;TM 5275;TM-5275

CAS NO.：1103926-82-4
Empirical Formula: C28H29ClN3NaO5
Molecular Weight: 546
MDL number: MFCD28396414
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is TM 5275?

Description

TM5275 is an inhibitor of plasminogen activator inhibitor 1 (PAI-1; IC₅₀ = 6.95 μM), a serine-protease inhibitor involved in thrombosis. TM5275 inhibits formation of a complex consisting of tissue plasminogen activator (tPA), PAI-1, and GFP on vascular endothelial cells (VECs) in vitro, prolonging the time that tPA is retained on VECs. It also enhances fibrin clot dissolution and plasminogen accumulation in vitro and has antithrombotic effects in rat models of thrombosis. TM5275 (10 and 50 mg/kg) decreases blood clot weight in an arteriovenous shunt thrombosis model and increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model when used at doses of 1 and 3 mg/kg. In a cynomolgus monkey model of photochemical-induced arterial thrombosis, TM5275 (10 mg/kg) increases the time to primary occlusion. It does not affect platelet activity, activated partial thromboplastin time, prothrombin time, or prolong bleeding time.

The Uses of TM 5275

TM 5275 Sodium Salt is a novel inhibitor of plasminogen activator inhibitor-1 (PAI-1), which provides antithrombitic benefits devoid of bleeding in primates.

Biochem/physiol Actions

TMS5275 is an orally available, potent and selective inhibitor of PAI-1 that delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates.

Storage

Store at +4°C

Properties of TM 5275

storage temp.	2-8°C
solubility	DMSO:20.0(Max Conc. mg/mL);36.77(Max Conc. mM) DMF:PBS (pH 7.2) (1:8):0.11(Max Conc. mg/mL);0.2(Max Conc. mM) DMF:33.0(Max Conc. mg/mL);60.66(Max Conc. mM)
form	powder
color	white to beige

Safety information for TM 5275

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P273:Avoid release to the environment.