thioperamide maleate salt

CAS NO.：148440-81-7
Empirical Formula: C15H24N4SC4H4O4
Molecular Weight: 0
MDL number: MFCD00083209
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is thioperamide maleate salt?

Description

Thioperamide (maleate) is a selective histamine H₃ receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pK_i value of 8.4 and inhibits histamine binding in vivo with an ED₅₀ value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.

The Uses of thioperamide maleate salt

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

What are the applications of Application

Thioperamide?maleate is a potent and selective histamine H3 receptor antagonist shown to cross the blood-brain barrier

Biochem/physiol Actions

Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

Properties of thioperamide maleate salt

storage temp.	desiccated under inert gas
solubility	H2O: >10mg/mL
form	solid
color	white

Safety information for thioperamide maleate salt

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.