thiocolchicine
Synonym(s):10-Demethoxy-10-(methylthio)colchicine;10-Thio-colchicine;N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-acetamide;NSC 186301
- CAS NO.：2730-71-4
- Empirical Formula: C22H25NO5S
- Molecular Weight: 415.5
- MDL number: MFCD01736965
- EINECS: 220-346-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 09:27:42
What is thiocolchicine?
Chemical properties
Bright Yellow Solid
The Uses of thiocolchicine
A muscle relaxant.
What are the applications of Application
Thiocolchicine is a specific tubulin synthesis inhibitor and Topo I inhibitor
Biochem/physiol Actions
Thiocolchicine is an antimitotic alkaloid and apoptosis inducer that inhibits tubulin polymerization and microtubule assembly.
Properties of thiocolchicine
| Melting point: | 193℃ |
| Boiling point: | 729.1±60.0 °C(Predicted) |
| alpha | D20 -221° |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 14.75±0.40(Predicted) |
| form | powder |
| color | white to beige |
Safety information for thiocolchicine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H318:Serious eye damage/eye irritation H340:Germ cell mutagenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for thiocolchicine
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