thielavin A
- CAS NO.：71950-66-8
- Empirical Formula: C29H30O10
- Molecular Weight: 538.54
- MDL number: MFCD11111622
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is thielavin A?
Description
Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 (PGH2; ) and the conversion of PGH2 to PGE2 (; IC50s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM).
The Uses of thielavin A
The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.
The Uses of thielavin A
Thielavin A acts as an inhibitor of prostagladins biosynthesis.
What are the applications of Application
Thielavin A is apotent prostaglandin synthetase inhibitor
Properties of thielavin A
| Melting point: | 235-236 °C |
| Boiling point: | 850.0±65.0 °C(Predicted) |
| Density | 1.371±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: souble; DMSO: souble; Ethanol: soluble |
| form | White to off-white powder. |
| pka | 2.82±0.28(Predicted) |
Safety information for thielavin A
Computed Descriptors for thielavin A
New Products
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