Tetrazine-Acid

CAS NO.：1380500-92-4
Empirical Formula: C10H8N4O2
Molecular Weight: 216.2
MDL number: MFCD24503098
Update Date: 2026-05-28 05:46:28

What is Tetrazine-Acid?

Description

Tetrazine-Acid was found the fastest kinetics for bioorthogonal reaction with trans-cyclooctene (TCO) as the dienophile. The chemical stability of tetrazines is lower compared to methyltetrazines, but it is in acceptable range and thus can be applied for many applications.

The Uses of Tetrazine-Acid

Tetrazine-acid demonstrates exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile (up to 30,000 M^-1 s^-1). These have been the fastest kinetics reported for a bio orthogonal reaction. The chemical stability of tetrazines is substantially lower compared to methyltetrazines, thus requiring more careful selection of reagents and conditions for chemical transformation. However, tetrazine chemistry is still in an acceptable range for many applications.

Properties of Tetrazine-Acid

Boiling point:	477.1±47.0 °C(Predicted)
Density	1.394±0.06 g/cm3(Predicted)
solubility	DMSO : 50 mg/mL (231.27 mM; Need ultrasonic)
pka	3.66±0.10(Predicted)
form	Solid
color	Pink to red

Safety information for Tetrazine-Acid

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02
GHS Hazard Statements	H242:Self-reactive substances and mixtures; and Organic peroxides
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P234:Keep only in original container. P235:Keep cool. P240:Ground/bond container and receiving equipment. P370+P378:In case of fire: Use … for extinction. P403:Store in a well-ventilated place.

Computed Descriptors for Tetrazine-Acid

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