Tetrahydrobiopterin
Synonym(s):(6R)-BH4
- CAS NO.：17528-72-2
- Empirical Formula: C9H15N5O3
- Molecular Weight: 241.25
- MDL number: MFCD00214397
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 10:51:09
What is Tetrahydrobiopterin?
The Uses of Tetrahydrobiopterin
Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative.
Definition
ChEBI: 5,6,7,8-tetrahydrobiopterin is a tetrahydropterin, a member of biopterins and a diol. It has a role as a prosthetic group, a coenzyme, a nutraceutical and a human metabolite.
Properties of Tetrahydrobiopterin
| Melting point: | >202°C (dec.) |
| Boiling point: | 506.6±60.0 °C(Predicted) |
| Density | 1.89±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly) |
| form | Solid |
| pka | 14.22±0.20(Predicted) |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for Tetrahydrobiopterin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tetrahydrobiopterin
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