tert-Butyl 2-bromo-4-fluorobenzoate

CAS NO.：889858-12-2
Empirical Formula: C11H12BrFO2
Molecular Weight: 275.11
MDL number: MFCD08703426
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:58:26

What is tert-Butyl 2-bromo-4-fluorobenzoate?

The Uses of tert-Butyl 2-bromo-4-fluorobenzoate

tert-Butyl 4-Bromo-2-fluorobenzoate is an intermediate of enzalutamide (M199800). Enzalutamide is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.

Properties of tert-Butyl 2-bromo-4-fluorobenzoate

Boiling point:	305.7±27.0 °C(Predicted)
Density	1.394±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
color	Clear Colourless

Safety information for tert-Butyl 2-bromo-4-fluorobenzoate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.