Terpendole E
Synonym(s):;1′α-Hydroxy-paspaline;FO 2546L
- CAS NO.：167427-23-8
- Empirical Formula: C28H39NO3
- Molecular Weight: 437.61
- MDL number: MFCD28346948
- Update Date: 2025-04-17 18:22:24
What is Terpendole E?
The Uses of Terpendole E
Acyl-coenzyme A:cholesterol acyltransferase (ACAT) isozymes are involved with cellular cholesterol esterification and regulate intestinal cholesterol absorption and hepatic lipoprotein secretion. Terpendole E is a related compound of Terpendole C (T116600), which is an inhibitor of ACAT1 and ACAT2 isozymes.
What are the applications of Application
Terpendole E is a ACAT and Eg5 inhibitor
Definition
ChEBI: Terpendole E is an organic heterotricyclic compound and an organooxygen compound.
Biochem/physiol Actions
Terpendole E is a mitotic kinesin Eg5 (Kinesin-5) inhibitor isolated from Albophoma yamanashiensis that inhibits both motor and microtubule stimulated ATPase activities of human Eg5. Studies indicate that Terpendole E inhibits Eg5 mutants resistant to S-trityl-L-cysteine and other Eg5 inhibitors. Also, Terpendole E is an ACAT (Acyl-CoA:cholesterol acyltransferase) inhibitor.
Properties of Terpendole E
| Boiling point: | 597.1±50.0 °C(Predicted) |
| Density | 1.194±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| form | powder |
| pka | 14.45±0.70(Predicted) |
| color | white to beige |
Safety information for Terpendole E
Computed Descriptors for Terpendole E
New Products
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