Teflubenzuron

The Uses of Teflubenzuron

Teflubenzuron is an benzoylphenylurea chitin synthesis inhibitor used to control a wide range of insect pests and mites in fruit, vegetable, cereal and seed crops.

The Uses of Teflubenzuron

uSE: Insecticide.

The Uses of Teflubenzuron

Teflubenzuron is used for the control of Lepidoptera, Coleoptera, Diptera, Aleyrodidae, Hymenoptera, Psyllidae and Hemiptera larvae on vines, pome fruit, citrus, vegetables, soyabeans, tobacco and cotton. It also controls fly and mosquito larvae and immature stages of locusts.

Definition

ChEBI: Teflubenzuron is a N-acylurea that is N-carbamoyl-2,6-difluorobenzamide substituted by a 3,5-dichloro-2,4-difluorophenyl group at the terminal nitrogen atom. It has a role as a xenobiotic, an environmental contaminant and an insecticide. It is a dichlorobenzene, a N-acylurea and a difluorobenzene. It is functionally related to a N-benzoylurea.

Metabolic pathway

There is limited published information on the metabolism of teflubenzuron but an IPCS review is in preparation. Metabolic processes reported are cleavage of the urea bond and hydroxylation of both phenyl rings, including replacement of a fluorine in the 3,5-dichloro-2,4-difluorophenyl ring (see Scheme 1).

Degradation

Teflubenzuron is more readily hydrolysed at alkaline pH than in acid media. The DT₅₀ at 50 °C was 5 days at pH 7 and 4 hours at pH 9 (PM).

Toxicity evaluation

Acute oral LD₅₀ for rats: >5,000 mg/kg